Cisplatin chemistry

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August undefined, 2024

WebCisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, … WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different …

Cisplatin Wiley Online Books

WebCisplatin is a tiny little drug molecule that contains a platinum ion in the middle of a flat square with two chloride ions and two ammonia molecules making up the corners. … WebCisplatin Cl2H6N2Pt CID 5460033 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity … how automatic content recognition acr works

Cisplatin in cancer therapy: molecular mechanisms of action

WebThe high stability of PTCG NPs during circulation stems from their strong metal-polyphenol coordination interactions, and efficient drug release is realized after cellular internalization. The activated cisplatin elevates the intracellular H 2 O 2 level through cascade reactions. Webtrans-Platinum(II) diamminedichloride Cl2H6N2Pt+2 CID 441203 - structure, chemical names, physical and chemical properties, classification, patents, literature ... WebNov 4, 2013 · Platinum compounds represent one of the great success stories of metals in medicine. Following the serendipitous discovery of the anticancer activity of cisplatin by Rosenberg, a large number of cisplatin variants have been prepared and tested for their ability to kill cancer cells and inhibit tumor … how auto leases work

Cisplatin: The first metal based anticancer drug - ScienceDirect

Development of HPLC conditions for valid determination of

WebSep 30, 2024 · Cisplatin resistance in tumor cells is known mainly due to the reduced accumulation of platinum ions by efflux, detoxification by intracellular GSH, and nucleotide excision repair machinery-mediated nuclear DNA repair. WebIn the 1960s the drug cis-platin was discovered, which has been extremely effective in treating a number of different types cancer such as testicular, ovarian, cervical, breast, lung and brain cancer. Cancer cells grow and replicate much faster than normal cells. Cis-platin is a square planar molecule that has a geometric isomer with the side ... how auto loan worksWebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … how automatic investment etf

"WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … " - Cisplatin chemistry

Cisplatin chemistry

Precisely Assembled Nanoparticles against Cisplatin Resistance via ...

WebJan 9, 2024 · Cancer Drug 49 Times More Potent than Cisplatin ... business news WebFeb 1, 2014 · Journal of Computational and Theoretical Nanoscience February 1, 2014. Behavior of one and two Cisplatin (Cp) molecules confined in (8, 0), (9, 0), (10, 0), (11, 0), (12, 0) (14, 0) and (9, 9) capped and opened single-walled carbon nanotubes (CNTs) is studied by means of ab-initio calculations. Optimized geometry of inclusion complexes …

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WebIntroduction: Cisplatin has been indicated for several malignancies all over the world for many years. Increasing patient tolerance for high dose of chemotherapeutics and reducing side effects has been granted by drug encapsulated liposomal systems. WebSpecifically, the following ionic compounds present in the nutrient medium formed oxidizing agents after electrolysis with platinum electrodes: ammonium sulfate ( (NH 4) 2 SO 4 ); ammonium carbonate ( (NH 4) 2 CO 3 ); ammonium chloride (NH 4 Cl); and other chlorides.

WebOct 5, 2014 · Cisplatin has a molecular weight of 301.1 gm/mol, a density of 3.74 g/cm 3, a melting point of 270° C, a log K ow of -2.19 and a water solubility of 2.53 g/L at 25° …

WebCisplatin / chemistry Cisplatin / metabolism* Colonic Neoplasms / metabolism* Colonic Neoplasms / pathology Copper / metabolism Copper / pharmacokinetics Copper Transporter 1 Dose-Response Relationship, Drug Homeostasis Humans Platinum / metabolism Platinum / pharmacokinetics Structure-Activity Relationship Substances Cation Transport Proteins WebApr 8, 2024 · 1 Beijing National Laboratory for Molecular Sciences; CAS Key Laboratory of Analytical Chemistry for Living Biosystems; National Centre for Mass Spectrometry in Beijing, Institute of Chemistry, ... (NH3)(thiazole)] (trans-PtTz) toward HeLa cells to a similar level of cisplatin, contributable to retarding the repair of 1,3-trans-PtTz crosslinked ...

WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. …

WebApr 15, 2024 · The treatment was well tolerated only he developed grade 2 mucositis and weight loss associated with cisplatin [ duration of treatment to reactions onset not stated … how auto loans work redditWebLTTs minimise cisplatin-induced DNA damage and evade apoptosis by increased expression of anti-apoptotic factors. The observed diversity among the four LTTs highlights the complexity of cisplatin resistance mechanisms even within one tumour entity, explaining heterogeneity in patient responses to chemotherapy. ... Chemistry 2016, 22, 8943 ... how many moles are in 34.4 g of water h2oWebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … how many moles are in 33.0 g of chloroethaneWebThis book compiles in six Parts the various aspects of chemistry, biochemistry, biology, pharmacology, and medicine relevant to cisplatin, describing new links that suggest how … how many moles are in 29.0 g of chloroethaneWebIn addition to solubility limitations, cisplatin has also been shown to be a highly reactive molecule. The reactivity of cisplatin and other platinum complexes towards many … how automation affects maritime industryWebThe microstructure and properties of metal ion-assisted cisplatin-loading SLNs were investigated by infra-red spectroscopy, fluorescence spectroscopy and zetasizer. The reactions of hydrogenated soybean lecithin with Zn(2+), Cu(2+), Mn(2+ )and Mg(2+ )have been detected; the mechanism for higher drug encapsulation efficiency (EE) has been ... how many moles are in 34 grams of cu oh 2WebApr 9, 1999 · 30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce … how automatic direction finder works