WebThe CYP17A1 enzyme catalyzes two distinct enzymatic steps in the steroidogenic pathway, the 17α-hydroxylase and 17,20-lyase. More than 90 mutations in CYP17A1 have been identified to date, including missense and nonsense mutations, insertions, deletions, and splice site variants (Kim et al., 2014 ). Mutations in the CYP17A1 gene cause a rare ... Webresistance to TMZ, and suggests that CYP17A1 participates in the malignancy process of glioma. However, the mechanism responsible for CYP17A1 upregulation in GBM …

Targeting molecular resistance in castration-resistant prostate …

WebApr 21, 2015 · CYP17A1 and AR would seem to be the two most important actors in the AR signalling axis in the acquisition of resistance to abiraterone treatment (Friedlander et al, 2012; Lin et al, 2013). WebAbiraterone acetate (AA) is the first-in-class of drugs belonging to the second-generation of agents inhibiting androgen neosynthesis in advanced prostate cancer. A cumulative experience attests that germinal gene polymorphisms may play a role in the prediction of anticancer agent pharmacodynamics variability. In the present prospective, multicentric … small tables at big lots

Abiraterone-Induced Endocrinopathies JCEM Case Reports

WebNational Center for Biotechnology Information WebMorusflavone, a flavonoid from Morus alba L., was evaluated for its interactive ability and stability with CYP17A1, in comparison with abiraterone, which is a Food and Drug Administration (FDA)-approved CYP17A1 inhibitor. CYP17A1 inhibition is an important therapeutic target for prostate cancer. The CHAMM36 force field was used to perform … WebMay 22, 2024 · Cytochrome P450 17A1 (CYP17A1), which converts pregnenolone to dehydroepiandrosterone (DHEA) in endocrine organs and the brain, is required for … small tables and 2 chairs