WitrynaA solution of 50 g. of p-tolylsulfonylmethyl isocyanide in 150 ml. of dichloromethane is placed on a 40 × 3 cm. column containing about 100 g. of neutral alumina slurried in dichloromethane. A nearly colorless solution ( ca. 700 ml.) is collected over about 1 hour. This solution is evaporated to dryness on a rotary evaporator, providing 42 ... Witryna1. Procedure. One mole of benzylmagnesium chloride is prepared in a 2-l. three-necked, round-bottomed flask from 24.3 g. (1 gram atom) of magnesium turnings, 126.5 g. …

Organic Syntheses Procedure

WitrynaOrthogonally protected chiral β-hydroxy-γ-amino acids can be accessed in >100 g quantities from readily available starting materials and reagents in three to four steps. the little sindy museum

Organic Syntheses Procedure - orgsyn.org

http://www.orgsyn.org/demo.aspx?prep=CV6P0774 WitrynaReaction mechanism. To illustrate the mechanism, the Japp-Klingemann ester variation will be considered. The first step is the deprotonation of the β-keto-ester. The nucleophilic addition of the enolate anion 2 to the diazonium salt produces the azo compound 3. Intermediate 3 has been isolated in rare cases. WitrynaIt melts at 65–71°. If pure ester is desired, it may be obtained by recrystallizing from petroleum ether (b.p. 70–90° ); the yield is 80–85 g. of ester melting at 74–75° from … thelittlesims